Digestive Diseases Center, Showa University Koto Toyosu Hospital

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POEM + F (POEM + Fundoplication)

A brand-new endoscopic procedure to prevent GERD after POEM
For Achalasia and related motility disorder patients


  • Since its introduction in 2008, peroral endoscopic myotomy (POEM) has become the minimally invasive endoscopic treatment of choice for achalasia.
  • Conventionally, Heller-Dor operation, consisting of Heller myotomy and Dor fundoplication, was the standard choice of treatment for achalasia patients. Because the operative method of POEM has device that preserves the reflux prevention function inherent in the living body, POEM consists of only myotomy part and initially does not need fundoplication part.
  • Although, recently, the incidence of gastroesophageal reflux (GER) post-POEM has been reported mainly in western countries.
  • To overcome this problem, as an option, we developed endoscopic partial fundoplication procedure added to the standard POEM procedure. We coined it “POEM + Fundoplication (POEM+F)” 1.
  • POEM+F consists of myotomy part (POEM) and fundoplication part (per-oral endoscopic fundoplication; POEF)2,3. We identify POEM+F as “endoscopic Heller-Dor”.


  1. POEM >> see POEM page
  2. POEF
    POEM is followed by POEF.
    POEF originally consists of the following 3 steps.

i) Submucosal tunneling

We use the same entry site and submucosal tunnel that was created during POEM procedure.

ii) Fundoplication

Submucosal endoscope is advanced through the peritoneum into the abdominal cavity. We carry the needle and make the distal anchoring at the anterior gastric wall by grasping the full thickness of the gastric wall (Fig. A). The second stitch is placed at the distal end of the exposed dissected muscle layer in the submucosal tunnel. By pulling back the scope and the device (Fig. B), suture is tightened up and partial wrap is created at the gastric cardia (Fig. C).

Fig.A: An illustration of POEF procedure. We use two endoscopes. One is in the peritoneal cavity which is used mainly for operation. The second endoscope is in gastric retroflex view to confirm the morphological change of the cardia and to assist the main scope.
Fig.B: An illustration of the result after POEF. Ideally, the shape of the cardia is similarly designed to that of Dor fundoplication.

iii) Mucosal closure

The entry site is completely closed by clips, same as in POEM procedure.

The morphological change at the gastric cardia (Achalasia patient).
Fig.A: Before POEM. The cardia is tightly closed.
Fig.B: After POEM. After myotomy, the cardia is widely opened.
Fig.C: After fundoplication (POEF). The cardia is covered again by the created floppy partial wrap.


This diagram shows our suggested treatment strategy for achalasia and related motility disorders. For cases without any risk of GERD, we perform standard POEM. For cases with high risk of GERD (yet it has not been revealed), we perform POEM+F from initial operation. When we encounter GERD in standard POEM, we perform Per-oral Endoscopic Fundoplication (POEF).

  • POEM+F and POEF procedure have been approved by the Ethics Board of Showa University Koto Toyosu Hospital.


  1. Inoue H, Ueno A, Shimamura Y, et al. Peroral endoscopic myotomy and fundoplication: a novel NOTES procedure. Endoscopy 2019; 51(2): 161-4.
  2. Goto O. et al. Endoscopic suturing for mucosal defects: feasibility of hand suturing in an in vivo.
  3. Toshimori A, Inoue H, Shimamura Y, et al. POEF- Per-Oral Endoscopic Fundoplication -A brand new intervention for GERD-;Video GIE (in press)